Abstract Snippets 2023
August 2023
Efficacy and safety of a targeted-release formulation of budesonide in patients with primary IgA nephropathy (NefIgArd): 2-year results from a randomised phase 3 trial
Synopsis
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Adult patients with IgA neuropathy, a kidney disorder, were enrolled in a phase 3 double-blind placebo-controlled study to find the efficacy of Nefecon.
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Glomerular filtration rate (eGFR) and urine protein were measured to assess improvement in kidney function.
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With Nefecon treatment, eGFR reduced from 35-90 ml/min to 5.05 ml/min. There were few adverse events and all patients survived.
Conclusion
Therefore, treatment with Nefecon improved kidney function by reducing eGFR and excessive urine protein.
December 2023
Human Blood Metabolites and Risk of Sepsis: A Mendelian Randomization Investigation
Synopsis
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The level of metabolites in the blood correlates with sepsis. However, it is unknown whether blood metabolites cause sepsis.
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This study evaluated 486 metabolites using genome-wide association studies (GWAS) data from 7824 individuals that were exposed, 11643 individuals with sepsis, and 474841 individuals that are controls.
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The study found that risk for sepsis is lower with high levels of metabolites such as 1-oleoylglycerophosphoethanolamine (odds ratio (OR) = .52, 95% confidence interval (CI): .31-.87, p = .0122), alpha-glutamyltyrosine (OR = .75, 95% CI: .60-.93, p = .0102), heptanoate (7:0) (OR = .51, 95% CI: .33-.81, p = .0041) and saccharin (OR = .84, 95% CI: .74-.94, p = .0036).
Conclusion
Therefore, increased level of blood metabolites results in a lower risk for sepsis.
Longitudinal Sleep Patterns and Cognitive Impairment in Older Adults
Synopsis
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Although irregular sleep patterns are associated with neurologic disorders, the effect of long-time or longitudinal sleep disturbances on cognitive function is unknown. The Seattle Longitudinal Study (SLS) evaluated sleep deprivation and cognitive function in older adults.
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This study reevaluated whether cognitive function declined with long-time sleep disturbances in 826 older adults. Men and women aged 76 years were assessed by the Mini Mental State Examination and the Mattis Dementia Rating Scale.
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The authors found that reduced sleep duration and high variability in sleep over time were associated with decline in cognition.
Conclusion
Therefore, this study showed that long-time sleep deprivation can lead to cognitive decline.